The most common Diflucan side effects are nausea or feeling sick, vomiting, headache, stomach pain, indigestion, diarrhea, and acne.1
More serious but far less common side effects of Diflucan are swelling of the face, lips or tongue; asthma, wheezing, shortness of breath; sudden or severe itching, skin rash, hives; fainting, seizures or fits; flaking of the skin; yellowing of the skin or eyes; bleeding or bruising more easily than normal, reddish or purplish blotches under the skin; signs of frequent or worrying infections such as fever, severe chills, sore throat or mouth ulcers; fast or irregular heart beat.1
Makes you feel unwell just reading through the possible - although not likely - list of Diflucan side effects!
With any of the serious side effects of Diflucan mentioned above, you need to immediately tell your doctor. Diflucan does react with a very LONG list of other medications so that it is advisable to always get Diflucan through your own doctor who knows your medical history and not buy through an online pharmacy. 50% of the online pharmacies are not based in the US and there are concerns with some of them about drug quality.
Diflucan is hard on the liver and is excreted through the kidneys so that if you have any medical problem with either organ make sure the prescribing doctor is aware of this.
If you're interested in how fast diflucan works then check this 2005 study.
Doctors commonly prescribe Diflucan for vaginal yeast infections (vaginal thrush, vulvovaginal candidiasis.) In a United States study of women prescribed Diflucan 150mg single dose (Diflucan One, Diflucan 1) for vaginal yeast infection 26% has side effects that MIGHT have been caused by the Diflucan.2
Treatment related adverse effects were headache (in 13% of the women), nausea (7%), abdominal pain (6%), diarrhea (3%), indigestion (1%), dizziness (1%), and strange taste in month (1%).2
This drug is found in human breast milk in high concentration so is not advised if a woman is breastfeeding.2
After years of sitting on the fence, in March of 2011 the U.S. Food and Drug Administration (FDA) came out to say that chronic, high doses (400-800 mg/day) of Diflucan (fluconazole) may be associated with rare types of birth defects in babies whose mothers were treated with the drug during the first trimester of pregnancy.
They are talking about the high dose and stress that this risk does not appear to be associated with a single, low dose of fluconazole 150 mg which is commonly used to treat vaginal yeast infection.
You can read more on this at FDA.
Tests on rabbits showed no effects of Diflucan on the fetus at 20 to 60 times the human dose although abortions occurred at the higher end of that range. In rats, there was fetal damage at the higher dosage. These were all much higher dosages than used to treat vaginal yeast infection.
The manufacturers advise "Diflucan should be used in pregnancy only if the potential benefit justifies the possible risk to the fetus." Mothers who were on a high dose 400 to 800mg of Diflucan for more than 3 months experienced multiple birth defects.3
You can get round all of these worries by using antifungal creams rather than the pills. Not as convenient, I know, but so much safer.
Diflucan works by stopping the fungi from reproducing. It also damages the cell wall of the fungi so that eventually it dies. It is effective against Candida albicans which is the usual Candida species responsible for vaginal thrush. It is not effective against Candida krusei.2
When taken by mouth for vaginal yeast infection the Diflucan will be absorbed to its maximum concentration by the vaginal tissue within 48 hours and by the vaginal fluid within 72 hours.2
The active ingredient is fluconazole.
The other Diflucan ingredients in the 150mg gelatin capsule shell are microcrystalline cellulose, dibasic calcium phosphate anhydrous, povidone, croscarmellose sodium, Red No. 40 aluminum lake dye, and magnesium stearate.2
If you do take Diflucan, do be sure to follow up your treatment with Fem-Dophilus or one of the other probiotics that contain Lactobacillus reuteri RC-14 and Lactobacillus rhamnosus GR-1. These two combined are the stars of women's urogenital health. Fem Dophilus will help to ensure that the yeast infection does not return.
REFERENCES for Diflucan Side Effects
1. Medsafe (Medical Safety Authority) website. www.medsafe.govt.nz/Consumers/CMI/d/DiflucanOral.htm
2. Pfizer(the makers of Diflucan) website. www.pfizer.com/files/products/uspi_diflucan.pdf
3. MedLine Plus
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Measures pH in the correct range for women's health