Probiotics and Ulcerative Colitis

The probiotic Mutaflor might be useful if you're living with ulcerative colitis.

I can list the trials where it maintained remission in ulcerative colitis and enthuse about how effective it is against diarrhea but the minute I mention it contains a strain of E coli I sense you backing away!

Well, come closer my friend, because Mutaflor really is one of the good guys.

Listen up - this supplement contains E. coli Nissle 1917, a probiotic with a long and interesting history. Back during WW1, when Shigellosis was make life in the trenches a living hell, one soldier was unscathed. Shigellosis is a particularly nasty type of diarrhea with cramp, vommitting and bloody faeces.

This interested microbiologist Alfred Nissle who studied the stools of more soldiers than any one man should have to and declared that the reason this one soldier was immune to the bloody thunderbolt tearing through the bowels of his comrades was because a useful bacteria named E. coli Nissle 1917 had set up home in his colon.

Long before antibiotics were doing their good work the probiotic in Mutaflor was helping save lifes against the ravages of infectious diarrhea. This probiotic strain is not some Johnny-Come-Lately but has been on the market for nearly 100 years for the treatment of diarrhea.

In Germany it is considered as effective as standard drug treatments for maintaining remission in ulcerative colitis.

That's is no mean feat to have doctors and scientist stating it is as effective as their best drugs in maintaining remission in ulcerative colitis.


Is Mutaflor right for you?

I honestly don't know.

Probiotics do different things for different people. Different strains of probitoics do different things.

But what I do know is that if you're struggling with this painful and distressing problem and looking for a more natural treatment for ulcerative colitis or infectious diarrhea, then Mutalflor has a good track record with this type of complaint.

It's worth trying.

But - it is expensive.

And it is getting harder and harder to source.

Unfortunately , with the new requirements for additional studies on some probiotics both US and Canada have stopped selling it.

Used to be on Amazon but can no longer be found there. One person said "put my IBS into semi-permanent remission".

Seems to be available in Germany and instructions here for advise on how to use the German sales page and Australia.

If you or a friend is travlling to Germany it would be worth while trying to buy it. Very commonly available in most pharmacies in Germany.


Why you should love Mutaflor

  • Gives protectection in animal models of inflammatory colitis
  • Gives anti-inflammatory and cytoprotective effects on the bowel mucosa
  • Protects T84 monolayers against barrier disruption by enteropathogenic E. coli (EPEC) infection
  • Limits the adherance of harmful pathogens sticking to the bowel
  • Enhances intestinal barrier function
  • And lastly because it deserves to be loved - how would you like having E coli as one of your relatives!

Unlike the harmful forms of Escherichia coli, the probiotic in this supplement lacks their virulence factors whilst at the same time it has a survival advantage over other strains of E. coli. That means it acutally protects you against it's nasty relative.

Now -aren't you feeling a little more kindly towards Mutaflor already!


1. Clinical use of E. coli Nissle 1917 in inflammatory bowel disease. Inflamm Bowel Dis. 2008 Jul; 14(7):1012-8.

2. Non-pathogenic Escherichia coli versus mesalazine for the treatment of ulcerative colitis: a randomised trial. Lancet. 1999 Aug 21; 354(9179):635-9.

3. Double-blind comparison of an oral Escherichia coli preparation and mesalazine in maintaining remission of ulcerative colitis. Aliment Pharmacol Ther. 1997 Oct; 11(5):853-8.

4. Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine. Gut. 2004 Nov; 53(11):1617-23.